Alzhiemer's: Can an ultrasound cure you?

Alzheimers is a condition where your memory, speech, and physical movement is impaired.

Can ultrasound waves help restore some of the capacity?

Before we understand that, let us first examine why we develop Alzheimers.

There is more than one theory, but the popularly accepted version is that amyloid-β builds up in our brain.

Amyloid-β forms between our neurons, impinging on their ability to transmit messages. Once impaired, the key role played by our brain - speech, memory and motor skills are affected.

So if anything can reduce the buildup of amyloid-β, it would be welcome.

Scientists experimented with ultrasound therapy on mice [see here].

The mice exhibited a loss of memory after the buildup of plaque. Once subjected to the ultrasound, the plaque significantly reduced, improving memory.

The clever technique used was designed to stimulate the brain’s immune cells, called microglia.

Once activated, these microglial cells were able to ingest the plaque and transport it into their lysosomes.

Lysosomes are specialized structures within cells that break down waste materials. Essentially, the ultrasound treatment enhanced the microglia’s ability to clear out harmful deposits.

The lymphatic drainage system that exists in your brain can then remove the dissolved plaque. In case you didn’t already know, the lymphatic drain runs every night when you sleep removing debris from your brain.

So should you go and get an ultrasound for yourself? Preventively, even if you don't have Alzheimer's?

There are several clinical trials [see here] that are ongoing to prove the efficacy of the treatment in humans. There apparently do not seem to be any side effects.

The treatment is non-invasive, which is usually considered a gold standard for desirable medical interventions.

So it does seem to hit all the right notes.

Consider ultrasound monitoring if you have a family history of Alzheimer’s or suspect you might be at risk. It may be worthwhile.

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